貴州省黔東南州凱里市劍輝化工制造有限公司

SR-121463ACAS185913-79-5


價格:8600元/公斤含量:99%包裝:25公斤
CAS185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化學(xué)名稱N-tert-Butyl-4-[5‘-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2‘-


oxospiro[cyclohexane-1，3‘-indolin]-1‘-ylsulfonyl]-3-methoxybenzamidefumarate
Thereductionofdiethyl3-(methoxymethoxy)glutarate(I)withLiAlH4inTHF 


gives3-(methoxymethoxy)pentane-1，5-diol(II)，whichistreatedwithTs-OHand 


TEAinTHFtoyieldthedisulfonate(III).Thecondensationof(III)with5-


ethoxyindolin-2-one(IV)bymeansoftBu-OKinTHFaffordsthespirocompound 


(V)，whichisdeprotectedwithHClinmethanoltoaffordthespiranicalcohol 


(VI).Theoxidationof(VI)withpyridiniumchlorochromate(PCC)overAl2O3 


providesthespiraniccyclohexanone(VII)，whichistreatedwith2-


chloroethanol(VIII)andMs-OHintoluenetogivetheketal(IX).Thereaction 


of(IX)withzincborohydrideandtrimethylsilylchlorideinethyl 


ether/dichloromethaneyieldsthe2-chloroethoxyderivative(X)，whichis 


condensedwith4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonylchloride 


(XI)bymeansoftBu-OKinTHFtoaffordtheadduct(XII).Finally，thetarget 


compoundisobtainedbycondensationof(XII)withmorpholine(XIII)bymeans 


ofNaIinDMF，followedbytreatmentwithfumaricacid.


Bromophenylethylketone23022-83-5
Alpha2114-00-3
UR1431Hydrochloride49656-78-2
3-Chloropropiophenone936-59-4
propiophenone93-55-0
ChloroephedrineHCL110925-64-9
chloroephedrine27270-80-0
PHENYLPROPANOLAMINE14838-15-4